Wellbutrin SR® Tablets for Depression

Bupropion SR is a sustained-release antidepressant for major depressive disorder. It helps rebalance norepinephrine and dopamine in the brain. This page explains uses, dosing, safety, and access with US delivery from Canada, including options for those paying without insurance.

What Wellbutrin SR Is and How It Works

Wellbutrin SR® is a branded form of bupropion hydrochloride in a twice-daily sustained-release tablet. This medicine belongs to the norepinephrine-dopamine reuptake inhibitor class. The exact antidepressant mechanism is not fully understood. It likely increases central norepinephrine and dopamine by inhibiting their reuptake. Unlike SSRIs, it has minimal direct serotonergic activity and is not a benzodiazepine or monoamine oxidase inhibitor. As sustained release bupropion, it is designed to release the drug gradually over several hours.

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For depression-related education, you can review condition pages such as Depression and browse our Antidepressant category.

Who It’s For

This treatment is indicated for adults with major depressive disorder. It is not approved for pediatric use. People with a history of seizures or a diagnosed eating disorder, such as bulimia or anorexia nervosa, should avoid bupropion. It can precipitate mania or hypomania in individuals with bipolar disorder; screening is recommended before starting therapy. This product is a generic for Wellbutrin SR for depression. A different brand of bupropion SR is approved for smoking cessation; see our Smoking Cessation page for general information.

Dosage and Usage

Follow your prescriber’s directions and the official label. A typical initiation schedule for adults is bupropion hcl sr 150 mg once daily in the morning for several days. If tolerated, many patients are then increased to 150 mg twice daily. Space doses at least 8 hours apart and avoid taking near bedtime to reduce insomnia. Swallow tablets whole; do not crush, chew, or split. Taking with food may reduce stomach upset. The dose may need adjustment in hepatic impairment or older adults; your clinician will determine an appropriate plan.

Strengths and Forms

This medicine is supplied as oral sustained-release tablets. Commonly available strengths include bupropion sr 100mg, 150 mg, and 200 mg. Packaging and manufacturer may vary by pharmacy. Availability of particular strengths can change; your prescriber may select an alternative strength if needed.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember unless it is close to the next scheduled time. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not take two doses at once. Maintain at least an 8-hour interval between doses to help reduce seizure risk.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from excess heat and moisture. Keep the bottle tightly closed and out of reach of children and pets. For travel, carry your medication in original labeled packaging, bring a copy of your prescription, and pack doses in your carry-on. You can use a reminder app or set calendar alerts so you do not miss doses across time zones.

Benefits

This treatment can help reduce depressive symptoms when used as prescribed. It is generally activating rather than sedating for many patients. It does not typically cause weight gain and may have a lower likelihood of sexual side effects compared with some SSRIs. Twice-daily sustained release may improve adherence compared with multiple immediate-release doses.

Side Effects and Safety

• Common: dry mouth, nausea, headache, insomnia, agitation, tremor
• Other reported: constipation, dizziness, increased sweating, sore throat

Serious risks include seizures, which are dose-related and more likely with certain risk factors. The medicine may increase blood pressure in some patients. Rare reactions include severe allergic responses and angle-closure glaucoma in susceptible individuals. Antidepressants carry a boxed warning for suicidal thoughts and behaviors in younger patients; monitor mood changes and report concerns to a healthcare professional.

Drug Interactions and Cautions

Do not use with a monoamine oxidase inhibitor, and allow at least 14 days between stopping an MAOI and starting bupropion. This medicine is a strong CYP2D6 inhibitor and can increase levels of medications metabolized by CYP2D6, including certain SSRIs, tricyclics, antipsychotics, beta-blockers, and type 1C antiarrhythmics. CYP2B6 inducers or inhibitors may alter exposure to bupropion. Use caution with dopaminergic agents. Combining with nicotine replacement can increase the risk of hypertension; monitor blood pressure. Avoid abrupt discontinuation of alcohol or sedatives while taking this therapy. For broader mental health context, see Abilify Uses.

What to Expect Over Time

Effects on mood can build gradually. Early in treatment, some people notice activation or trouble sleeping; taking the second dose late in the day can worsen insomnia. Keep regular follow-ups so your prescriber can assess response and tolerability. Maintain consistent daily timing and avoid missed doses. For supportive reading, visit World Mental Health Day.

Compare With Alternatives

An extended-release once-daily version, Wellbutrin® XL, may suit those preferring a single morning dose. An SSRI such as Escitalopram is another common option for major depression. Other SSRIs, including fluoxetine or sertraline, may be considered based on clinical history and tolerability.

Pricing and Access

The bupropion sr price is shown after you select strength and quantity. US consumers benefit from Canadian pharmacy pricing; this product Ships from Canada to US. We offer encrypted checkout and clear billing. For current offers, see our Promotions page when available. If you are comparing options, review Bupropion SR Canadian pricing next to similar therapies in our catalog.

Availability and Substitutions

Stock can vary by strength and manufacturer. If a specific tablet is unavailable, a prescriber may recommend a therapeutically equivalent alternative. Your pharmacy will dispense a suitable generic that meets regulatory standards unless your prescription specifies otherwise.

Patient Suitability and Cost-Saving Tips

People with seizure disorders, eating disorders, or those undergoing abrupt withdrawal from alcohol or sedatives should not use this medicine. Those with bipolar disorder require careful evaluation. To manage out-of-pocket costs, consider larger fills if appropriate, compare generics within the class, and align refills with prescriber follow-ups. Multi-month supplies can reduce per-fill fees. Set refill reminders so you do not run out between appointments.

Questions to Ask Your Clinician

• Is this treatment appropriate for my depression history and symptoms?
• How should I time doses to reduce insomnia and jitteriness?
• What signs of adverse effects should prompt a visit or call?
• Could my other medications interact through CYP2D6 or CYP2B6 pathways?
• What monitoring do you recommend for blood pressure or mood changes?
• If I miss a dose, what should I do the same day?
• When might we reassess dose, formulation, or alternative options?

Authoritative Sources

• FDA DailyMed
• US Prescribing Information
• Health Canada Drug Product Database

Ready to proceed? Place your request with temperature-controlled handling when required and prompt, express shipping, with US shipping from Canada. This content is for general information and does not replace the official label or your prescriber’s advice.