Trulyicity® Pens for Type 2 Diabetes

Once-weekly dulaglutide is a GLP-1 receptor agonist used to improve blood sugar in adults with type 2 diabetes. It is a single-use, prefilled injection pen designed for simple, once-weekly dosing. This page explains how it works, who may benefit, label-based dosing, and how to access it with US delivery from Canada, including options if you pay without insurance.

What Trulicity Is and How It Works

Trulicity® contains dulaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist. It activates GLP-1 receptors to increase glucose-dependent insulin secretion, reduce glucagon release, and slow gastric emptying. Together, these actions can help lower fasting and post-meal glucose when used with diet and exercise.

CanadianInsulin.com is a prescription referral platform. We verify prescriptions with your prescriber when required, and licensed Canadian pharmacies dispense your order.

The autoinjector is single-use and given once weekly, on the same day each week, with or without food. It can be combined with other antihyperglycemics when a clinician decides combination therapy is appropriate.

Who It’s For

This treatment is indicated for adults with type 2 diabetes to improve glycemic control as an adjunct to diet and exercise. It may also be used to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease, based on approved labeling.

It is not for type 1 diabetes and not for treating diabetic ketoacidosis. People with a personal or family history of medullary thyroid carcinoma (MTC) or with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use it. Those with prior serious hypersensitivity to dulaglutide should avoid it. Discuss severe gastrointestinal disease, pancreatitis history, significant kidney disease, or gallbladder disease with a healthcare professional before starting.

Dosage and Usage

The pen is injected subcutaneously once weekly in the abdomen, thigh, or upper arm. Use the same day each week, any time of day. If needed, you may change the weekly day, provided at least 3 days have passed since the last dose.

Typical label-based initiation starts at a lower weekly dose, with stepwise escalation if additional glucose lowering is needed and tolerated. Dose adjustments should follow the official prescribing information and your prescriber’s direction.

When used with insulin or a sulfonylurea, the risk of hypoglycemia may increase. Monitor blood glucose closely, especially during titration. Alcohol intake, poor oral intake, and dehydration can increase adverse effects. Read the Instructions for Use included with the pen before the first dose.

Strengths and Forms

This once-weekly medicine is supplied as single-use, prefilled autoinjector pens. Four weekly dose options exist, ranging from low to higher-strength pens, spanning 0.75 mg to 4.5 mg. Availability may vary by pharmacy and region.

People often research Dulaglutide 1.5 mg price when comparing intermediate weekly doses. Actual out-of-pocket amounts depend on pharmacy inventory, supply cycles, and your prescription.

Missed Dose and Timing

If you miss a dose, take it as soon as possible if there are at least 3 days (72 hours) until your next scheduled dose. If fewer than 3 days remain, skip the missed dose and take the next dose on the regularly scheduled day. Do not take two doses within 3 days of each other. If repeated doses are missed, consult your prescriber for guidance according to the official label.

Storage and Travel Basics

Store unused pens in the refrigerator in the original carton to protect from light. Do not freeze. If a pen has been frozen, do not use it. According to commonly published guidance, a pen may be kept at room temperature for a limited time; check the current label for the exact window and maximum temperature. Keep out of reach of children.

When traveling, carry pens with you rather than checking them in luggage. Use insulated storage and coolant packs to maintain temperature during transit, avoiding direct contact with ice. If flying, bring your prescription, product label, and a copy of the Instructions for Use. Dispose of used pens safely after injection and do not reuse them.

Pen Handling and Sharps Disposal

Each prefilled autoinjector is single-use. Wash and dry your hands, inspect the pen and solution through the viewing window, and follow the step-by-step Instructions for Use. Inject into recommended subcutaneous sites and rotate locations each week. Never share the pen, even if a new needle would be used.

After using the pen, place the entire device in an FDA-cleared sharps container. If one is unavailable, use a heavy-duty household container with a tight-fitting, puncture-resistant lid. Follow your local rules for sharps disposal. Do not throw the used device in household trash or recycling.

Benefits

This GLP-1 therapy offers once-weekly dosing and a hidden needle design. It can be used alone or with other glucose-lowering medicines. Many patients appreciate the consistent weekly routine, which may support adherence. The class has evidence for cardiovascular risk reduction in adults with type 2 diabetes and established cardiovascular disease, as reflected in labeling for certain agents in this category.

Side Effects and Safety

• Gastrointestinal effects: nausea, vomiting, diarrhea
• Decreased appetite and dyspepsia
• Abdominal pain or bloating
• Fatigue or mild headache

Serious risks can include pancreatitis, gallbladder disease, acute kidney injury from dehydration, and severe hypersensitivity. GLP-1 receptor agonists carry a boxed warning for the risk of thyroid C-cell tumors in rodents; human relevance is unknown. Do not use if you or a family member has had MTC or MEN 2. Hypoglycemia can occur when combined with insulin or a sulfonylurea. Seek medical help for severe abdominal pain, persistent vomiting, signs of an allergic reaction, or symptoms suggestive of pancreatitis.

Drug Interactions and Cautions

Use caution when combining with insulin or sulfonylureas due to hypoglycemia risk. Because GLP-1 therapies can slow gastric emptying, absorption of some oral drugs may be affected, especially those with a narrow therapeutic index. Monitor when starting or changing doses of anticoagulants, digoxin, or other critical medications. Tell your healthcare professional about all prescription drugs, OTC medicines, vitamins, and herbal supplements you use.

What to Expect Over Time

Weekly dosing creates a steady routine. Gastrointestinal effects often appear early and may lessen as your body adapts. Diet quality, hydration, and taking time to eat smaller meals can help tolerance. Blood glucose responses vary; your prescriber will review results from home monitoring and lab tests over time to decide whether dose adjustments are appropriate. Continue lifestyle measures and keep regular follow-ups.

Compare With Alternatives

Other GLP-1 receptor agonists can be appropriate, depending on your clinical needs and tolerance. Ozempic® Pens are a weekly semaglutide option with different starting and target doses. Mounjaro® is tirzepatide, a dual GIP/GLP-1 receptor agonist, offering a different mechanism within the incretin pathway. Discuss suitability and titration with your prescriber. Searches for Dulaglutide injection price reflect interest in comparing GLP-1 options across the class; exact amounts vary by product and fill quantity.

Pricing and Access

Canadian pharmacy pricing can differ from US retail, and selection may vary over time. People researching Trulicity price often want to understand typical cash-pay ranges before deciding on a fill or refill.

We provide transparent product pages with current availability. If you pay out of pocket, you may compare Trulicity price without insurance to other GLP-1 agents, then choose the weekly supply that fits your prescription. For periodic offers, see our Promotions page.

Orders Ships from Canada to US with clear checkout steps. For help estimating total costs, contact support before placing an order; we can clarify fill sizes and dispensing pharmacies without giving medical advice.

Availability and Substitutions

Supply can fluctuate due to manufacturing, demand, and distribution. If a specific strength or package is temporarily unavailable, your prescriber may recommend an alternative GLP-1 option or an interim dose plan consistent with the label. Some customers compare Dulaglutide price with related agents when considering short-term substitutions.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with type 2 diabetes who need additional glucose lowering after lifestyle measures and first-line agents. It is not appropriate for those with MTC, MEN 2, or prior serious hypersensitivity to dulaglutide. If you have severe gastrointestinal disease, pancreatitis history, advanced kidney disease, or gallbladder disease, discuss risks and monitoring with your prescriber first.

Cost-saving tips include requesting multi-month fills when appropriate, aligning refills with routine lab visits, and avoiding missed doses that waste pens. Consider scheduling reminders on your phone for the weekly dose and reordering. If paying cash, you can review Trulicity cash price on the product page and compare against other GLP-1 options. For learning resources on therapy choices, explore our category pages for Non Insulin Injectables and Blood Sugar Control.

Questions to Ask Your Clinician

• Weekly dose plan: where to start and when to escalate
• Combination therapy: whether to adjust insulin or a sulfonylurea
• GI tolerance: diet tips and when to call for help
• Pancreatitis risk: personal history and symptom monitoring
• Kidney and gallbladder risk: labs and warning signs
• Oral medicines: any absorption concerns for narrow-index drugs
• Travel: storage, documentation, and timing across time zones

Authoritative Sources

Eli Lilly Trulicity Prescribing InformationFDA DailyMed: TrulicityHealth Canada Drug Product Database

Storage and Travel Basics

For more on diabetes care, see our Type 2 Diabetes hub and this helpful Dosage Chart article. Always verify your dosing schedule with a healthcare professional if anything is unclear.

Ready to proceed? You can Buy Trulicity online with express, US shipping from Canada and temperature-controlled handling when required. Prescription required. This content is for general information and does not replace your prescriber’s advice. Always follow the official label.