Hyzaar (losartan / hydrochlorothiazide tablets)

This product page summarizes a prescription tablet used to treat hypertension (high blood pressure) in appropriate patients. It explains what the medicine contains, how it is typically used, and key safety points to review with a clinician. It also outlines how access works through a prescription referral platform, including documentation steps.

Hyzaar is a fixed-dose combination tablet that includes an angiotensin II receptor blocker (ARB) plus a thiazide diuretic (water pill). A prescriber may choose this combination when one medicine alone does not control blood pressure. This page focuses on practical basics such as strengths, monitoring topics, and storage, without replacing individualized medical guidance.

What Hyzaar Is and How It Works

This medicine combines losartan (an ARB) and hydrochlorothiazide (a thiazide diuretic). Losartan relaxes blood vessels by blocking the effects of angiotensin II, a hormone that narrows arteries and signals the body to retain sodium. Hydrochlorothiazide helps the body remove extra sodium and water through the kidneys, which can reduce fluid volume and support blood pressure lowering. Using both agents together can address blood pressure through two different pathways.

Ships from Canada to US. CanadianInsulin.com is a prescription referral service. The combination is used for blood pressure control, not for quick symptom relief, and its full effect is assessed over time with repeat readings. Because hydrochlorothiazide increases urine output, changes may be noticed earlier in the day depending on timing. A clinician may also consider kidney function and electrolytes (blood salts) when selecting a combination product.

Who It’s For

This treatment is commonly prescribed for adults with hypertension when combination therapy is appropriate, including people who have not reached target readings on a single agent. It may also be selected when a clinician wants the convenience of one tablet rather than separate medicines. Some patients are switched from individual components to a fixed-dose tablet to simplify a regimen.

Contraindications and major cautions are important to review. ARB-containing products should not be used during pregnancy because they can harm the developing fetus, especially in the second and third trimesters. This therapy may be unsuitable in people with severe kidney impairment, very low blood pressure, significant dehydration, or a history of serious hypersensitivity reactions to components. Hydrochlorothiazide is a sulfonamide-derived diuretic; prior severe reactions to sulfonamide medicines should be discussed with the prescriber.

For related condition information and medication categories on the site, browse the Hypertension Hub or the Cardiovascular Category of prescription products.

Dosage and Usage

Fixed-dose losartan/hydrochlorothiazide tablets are typically taken once daily, with the exact strength and schedule determined by the prescriber. Clinicians often individualize dosing based on prior therapies, current blood pressure readings, kidney function, and lab values such as potassium and sodium. Some patients begin with lower strengths and are adjusted as needed, while others transition from separate tablets at comparable doses.

Hyzaar tablets are swallowed with water and can usually be taken with or without food. Because the diuretic component can increase urination, prescribers may recommend morning dosing to reduce nighttime bathroom trips. Missed-dose instructions vary by label and clinical situation, but combination blood pressure medicines are generally not doubled up; patients are commonly advised to resume the next scheduled dose and ask a pharmacist or prescriber when unsure.

For broader context on blood pressure medication classes, the site’s Cardiovascular Articles collection includes condition-focused guides.

Strengths and Forms

This product is supplied as an oral tablet (sometimes listed as a “tab”). Commonly referenced strengths include losartan/hydrochlorothiazide 50 mg/12.5 mg, 100 mg/12.5 mg, and 100 mg/25 mg. Availability can differ by pharmacy source and jurisdiction, so the exact presentation may vary even when the active ingredients match.

When reviewing a listing, confirm the two numbers correspond to losartan first and hydrochlorothiazide second. This matters because different combinations may be used for different stages of titration. A pharmacist can also help confirm whether a generic for the brand uses the same dose pairing and tablet appearance, since manufacturers may use different shapes, colors, or imprint codes.

Storage and Travel Basics

Most losartan/hydrochlorothiazide tablets are stored at controlled room temperature in a tight container, protected from moisture and excess heat. Keep the bottle closed between doses to reduce humidity exposure, and avoid storing tablets in a bathroom medicine cabinet if it is frequently steamy. Do not use tablets past the labeled expiration date.

Quick tip: Keep an up-to-date medication list in your wallet or phone.

For travel, carry the medicine in its original labeled container to reduce confusion at security checkpoints and during medical visits. If using a pill organizer, keep the pharmacy label or a photo of it available. If significant vomiting, diarrhea, or poor fluid intake occurs during travel, dehydration risk may increase; a clinician may want to review whether blood pressure medicines and diuretics should be held temporarily in certain acute illnesses.

Side Effects and Safety

Common effects relate to the way blood pressure medicines work and the added diuretic. Some people notice dizziness, especially when standing up quickly, fatigue, or mild stomach upset. Hydrochlorothiazide can increase urination and may cause electrolyte shifts such as low sodium or low potassium, while ARBs more commonly raise potassium in some patients. Sensitivity to sunlight and skin rash can occur with thiazide diuretics.

More serious reactions are uncommon but clinically important. Very low blood pressure can lead to fainting, particularly in people who are volume-depleted or taking other antihypertensives. Kidney function can worsen in susceptible patients, especially with dehydration, renal artery stenosis, or certain interacting medicines. Seek urgent care for swelling of the face, lips, tongue, or throat (angioedema), severe skin reactions, or eye pain and sudden vision changes (rare acute angle-closure glaucoma reported with hydrochlorothiazide).

Why it matters: ARB-containing medicines are avoided in pregnancy due to fetal kidney and development risks.

Monitoring topics often discussed

Clinicians commonly monitor blood pressure trends and basic labs after starting or changing a dose. Kidney function is assessed with serum creatinine and estimated glomerular filtration rate (eGFR), and electrolytes such as potassium and sodium are checked to detect imbalances early. People with diabetes may need additional monitoring because thiazide diuretics can affect glucose control in some cases. Home blood pressure readings can be helpful when taken consistently, using validated cuffs and proper technique.

Prescriptions on this platform may be verified with the prescriber when required. If symptoms such as muscle cramps, marked weakness, palpitations, confusion, or persistent dizziness occur, they should be reported promptly, since they can signal blood pressure that is too low or electrolyte disruption. Any sudden change in urine output, swelling, or shortness of breath also warrants clinical evaluation.

Drug Interactions and Cautions

Several interactions are relevant for ARB/diuretic combinations. Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce antihypertensive effect and, in some patients, increase the risk of kidney problems—especially when combined with a diuretic and an ARB. Potassium supplements, potassium-based salt substitutes, and other agents that raise potassium may increase the risk of hyperkalemia (high potassium). Lithium levels can rise with diuretics and some blood pressure medicines, so close monitoring is used when they must be combined.

Other cautions include alcohol (which can worsen dizziness), other blood pressure agents (additive hypotension), and certain diabetes medicines (thiazides may affect glucose in some individuals). Cholestyramine and colestipol can reduce absorption of hydrochlorothiazide if taken at the same time. Always share a complete medication list, including over-the-counter pain relievers and supplements, to help a pharmacist screen for avoidable combinations.

For background on related cardiovascular therapies, these articles may help with terminology: Benazepril Uses And Kidneys and How Bystolic Helps Control.

Compare With Alternatives

Clinicians choose among many options for hypertension, and the best fit depends on comorbidities, prior response, and lab values. One alternative is using the two components separately, which allows finer dose adjustments (for example, changing the ARB dose without changing the diuretic dose). Another alternative is switching within the ARB class or using a different combination product if side effects or lab changes occur.

Examples of related therapies include single-ingredient ARBs such as Losartan, or other ARB/thiazide combinations such as Diovan HCT. ACE inhibitors and calcium channel blockers are also widely used classes; selection is guided by kidney function, potassium levels, pregnancy status, and prior adverse reactions. If cough occurs on an ACE inhibitor, an ARB is sometimes considered instead, while edema can be a limiting effect for some calcium channel blockers.

For additional reading on ACE inhibitor terminology, see How Altace Supports Heart or the broader beta-blocker discussion in Atenolol And Hypertension Guide.

Pricing and Access

Access can depend on the prescribed strength, local dispensing rules, and whether a brand-name or generic drug for the combination is selected. For people managing Hyzaar without insurance, cash-pay options may be relevant, but total out-of-pocket amounts vary by pharmacy source and dispensing fees. If site promotions are available at the time of request, they are listed on Current Promotions.

Dispensing is completed by licensed Canadian pharmacies after prescription requirements are met. If the clinician changes therapy or dose, an updated prescription is needed before a different strength can be supplied. Patients should also keep routine follow-up for blood pressure checks and labs, since changes in kidney function or electrolytes may not cause early symptoms.

Authoritative Sources

For label-level details on indications, contraindications, and interactions, consult official references. These sources can help confirm dosing language, monitoring recommendations, and risk statements for losartan/hydrochlorothiazide combinations.

• For U.S. labeling, review DailyMed drug labels
• For patient-friendly summaries, see MedlinePlus medication resources
• For hypertension basics, read American Heart Association guidance

Information in labels is updated over time, and specific product monographs can differ by country and manufacturer. When reviewing any source, match the active ingredients and tablet strengths to the prescription on file.

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This content is for informational purposes only and is not a substitute for professional medical advice.